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OECD 451/OCSPP 870,42: Carcinogenicity studies

OECD 451/OCSPP 870,42: Carcinogenicity studies

Carcinogenicity studies provide guidance on the 18-30 month observation of mice and rats for development of neoplastic lesions when exposed to various doses of test substance. 

Administration routes (oral, dermal or inhalation) depend on the toxicokinetic profile/physical characteristics of the test substance. 

Daily or weekly (more thorough) observation reports include animal weight, skin/fur evaluation and activity levels. 

Blood counts, necropsy and histopathology are also performed.

Models

Mouse, Rat

Administration Routes

Gavage, Dietary

Industry Market

Crop, Chemical

Phase

Nonclinical