Online Catalog

Search for common nonclinical studies and assays; customization is possible.

OECD 422: Combined repeated dose toxicity study (w/screening)

OECD 422: Combined repeated dose toxicity study (w/screening)

The objectives of the Combined Repeated Dose Toxicity Study with the reproduction/developmental toxicity screening test are to examine chemical exposure on male and female reproductive performance, in addition to the standard requirements for Repeat Dose General Toxicity studies of 4-week duration (OECD 407). 

The study design is a combination of the OECD 421 test guideline and the OECD 407 test guideline and therefore adds additional endpoints including clinical pathology, full histopathology and neurobehavioral assessments.

 

Combined Repeated Dose Toxicity Study with the Reproduction/Development Toxicity Screening Test

 

 

 

Models

Rat

Administration Routes

Gavage, Dietary

Industry Market

Chemical

Phase

Nonclinical