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OECD 416: Two-generation reproduction toxicity

OECD 416: Two-generation reproduction toxicity

The objectives of the two-generation reproductive toxicity study are to detect adverse effects on integrity and performance of the male and female reproductive systems, and on the growth and development of the offspring. The conduct of this study should provide a satisfactory estimation of a no-observed-adverse-effect level (NOAEL) and an understanding of adverse effects on reproduction, parturition, lactation and postnatal development including growth and sexual development.

The OECD 416 study is primarily conducted in rodents via dietary or oral gavage routes of administration.

 

Two Generation Reproduction Toxicity Study

 

 

Models

Rat

Administration Routes

Gavage, Dietary

Industry Market

Crop, Chemical, Pharma

Phase

Nonclinical