Online Catalog
A collection of nonclinical studies & assays; customization is possible.

In vitro cytochrome (CYP) induction

In vitro cytochrome (CYP) induction

The induction of drug metabolizing CYP-enzymes can have significant pharmacological and toxicological consequences. To predict CYP induction in vitro, monolayer cultures of human hepatocytes are used as a model.

Regulatory guidance advocates the use of CYP mRNA expression as the preferred endpoint for the quantification of induction.